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Around 16 million Americans every year suffer from depression, with 32.5 years old as the median age of onset. Depression is the leading cause of disability in the United States. Everyone feels down once in a while and may even have bouts of depressive moods. However, depression is a more persistent experience of lack of energy, negative thoughts, and a desolate outlook in life. Someone who has felt sad and miserable most of the time for more than two weeks and/or has had some of the following signs.